Abstract
The aim of the present study was to evaluate the effect of magnesium oxide nanoparticles and the role of the harmonic scalpel in lung tissue healing at the site of a middle lobe resection of the right lung. Twenty-four adult domestic dogs were used. They were randomly divided into two equal groups (control and treated group). The middle lobe of the right lung was excised by harmonic scalpel with titanium clamps to control bleeding and infiltration of air bubbles. The clinical and physiological condition of the animals was studied in the two-week period after surgery and molecular evaluation at time of zero, first, third, fifth, seventh, fourteenth, twenty-first, twenty-eighth, and thirty-fifth days after operation by interleukin-6 and tumor necrosis factor-α. The result of clinical observation showed that dogs in both groups took 2-4 days after the operation to gain full activity. The heart and respiratory rate were within the normal level before and during the operation, and when the animal began to recover, the heartbeat and respiratory rate began to rise with irregularity and the irregularity continued for 3-5 hours after the completion of the operation and then returned to its normal level within 24 hours after the operation. These changes in heart rate and respiratory system were observed in all treated animals, while heart rhythm and respiratory rates persisted in the control group until several days after the operation. In the molecular evaluation, the results for interleukin-6 and tumor necrosis factor-α showed a significant difference in the mean values of these two factors between control and treated.
Highlights
Lung can be involved in a variety of disease processes, including cancer, trauma, lung lobe torsion, chronic lung diseases and cystic fibrosis
The heart and respiratory rate were within the normal level before and during the operation, and when the animal began to recover, the heartbeat and respiratory rate began to rise with irregularity and the irregularity continued for [3,4,5] hours after the completion of the operation and returned to its normal level within 24 hours after the operation
These changes in heart rate and respiratory system were observed in all treated animals, while heart rhythm and respiratory rates persisted in the control group until several days after the operation
Summary
Lung can be involved in a variety of disease processes, including cancer, trauma, lung lobe torsion, chronic lung diseases and cystic fibrosis. In some of these diseases, treatment usually depending on removing of lung lobes to cure them (1). Ultrasonic harmonic scalpel dissection devices have been introduced as an alternative to electrosurgical devices. These devices use ultrasonic waves to dissect the tissue, making it possible to perform a more sophisticated dissection with a narrower circumference of collateral thermal damage to the surrounding tissue compared to the damage caused by monopolar electrosurgical devices. MgO has good bioactive capabilities, biocompatibility, and magnesium ions have no toxicity (7). MgO NP is one of nanomaterials whose effects on living cells are persisted not known (8)
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