Abstract
Effect of an antibiotic, mycophenolic acid, on the development of mouse embryos in culture was compared to that of α-amanitin. The very early stages of the embryos were insensitive to mycophenolic acid, while they were sensitive to a-amanitin. The first obvious effect of mycophenolic acid was observed at late 8-cell stage. The compaction was inhibited and the cells in the embryos were degenerated by further incubation with mycophenolic acid (10 μg/ml). The embryos at later stages were more sensitive to this antibiotic than 8-cell embryos: 1 μg/ml of mycophenolic acid inhibited blastocyst formation partially but signi-ficantly, while earlier stages were insensitive to mycophenolic acid at this concentration.
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