Abstract
Stereoselective HPLC separations of five sterically constrained monoterpene-based 2-aminocarboxylic acid enantiomers were carried out by using the newly developed zwitterionic chiral stationary phases Chiralpak ZWIX(+)™ and ZWIX(-)™ based on Cinchona alkaloid. In order to optimize the retention and enantioselectivity parameters, the ratio of the different organic solvents in the mobile phase and the nature of the acid and base additives (counter- and co-ions) were systematically varied. The effects of structure variants of the analytes on the resolution were investigated. The elution sequence was determined in all cases and observed to be opposite on ZWIX(+)™ and ZWIX(-)™.
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