Effect of miglitol administration to non-insulin-dependent diabetic rats

Abstract

1. 1. The effect of the acute or chronic oral administration of miglitol (Bay M 1099 α-glucosidase inhibitor) to non-insulin-dependent diabetic rats was studied. 2. 2. The acute oral administration of miglitol (10 mg/kg b.w.) reduced significantly the increment of blood glucose after oral maltose (2 g/kg b.w.) overload (364 ± 58 and 205 ± 12 mmol/90 min, without and with miglitol respectively; P<0.05). 3. 3. Under chronic oral administration of miglitol (10 mg/kg b.w.), two days after the start of treatment the blood glucose dropped from 7.53 ± 9.59 to 4.40 ± 5.50 mmol/l. The plasma insulin, cholesterol, or triglycerides levels were not modified. 4. 4. A significant reduction ( P<0.01) in water and food intake was observed. Normal rats values were not affected by miglitol treatment.