Abstract
Objective To observe the therapeutic effect of micro-dose heparin on coagulation disorders in very early preterm infants.Methods One hundred and forty-seven preterm newborns with less than 34 weeks and abnormal coagulation function within 1 hour were included and randomly divided into two groups,one of which treated with heparin(10 U/kg) added into 2 ml normal saline via intravenous injection,the other given 2 ml normal saline via intravenous injection,every 8 hours,for 3 days.Both groups were given the routine therapy according to their primary diseases.The levels of TT,APTT,PT,FIB,D-Dimer and PLT were monitored at one hour and one week,and cranial ultrasound were monitored in one week.Results The levels of PT,APTT,D-Dimer decreased significantly and FIB increased significantly 1 week after therapy in both groups(P ＜ 0.05).There were significant differences in PT,APTT and FIB between the two groups 1 week after therapy (P ＜ 0.05).The rates of intracranial hemorrhage between the two groups had no significant difference (P ＞ 0.05).Conclusions Micro-dose heparin is safe and effective for preterm neonate coagulation disorders and it is suitable for clinical practice. Key words: Heparin; Very early preterm infants; Coagulation; Intracranial hemorrhage
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