Abstract
SummaryThe diuresis induced by intramuscular injections of mercuhydrin at varying time intervals following intravenous or oral administration of Sr85 was associated with an inconsistent and only slight increase in urinary Sr85 excretion despite a concomitant increase in urinary calcium excretion. Following the discontinuation of mercuhydrin there was marked inhibition of the urinary excretion of Sr85 and calcium. Further increase in urine volume induced by mercuhydrin used in conjunction with ammonium chloride resulted in a marked increase in urinary calcium but not in further enhancement of Sr85 excretion. Mercuhydrin actually diminished the effect of ammonium chloride by inhibiting radiostrontium excretion following discontinuation of this combined therapy. This rebound inhibition of Sr85 excretion contrasts with the sustained increase in Sr85 and calcium excretion following the discontinuation of ammonium chloride.
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Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
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