Abstract
Effect of mebicar on the epileptic activity (EA) and frequency of interepileptic activity discharges (IEAD) was studied in experimental focal cortical epilepsy induced by penicillin application to the sensomotor cortex of conscious rats. Mebicar in a dose of 300--100 mg/kg induced a dose-dependent suppression of EA in the presence of the increased frequency of IEAD. During rhythmic stimulation of some areas of the thalamus mebicar completely abolished high-frequency EA, promoting consecutive alternating on the electrocorticogram of periods of responses to each stimulus with dead bands. The antiepileptic effect of mebicar was compared with that of diazepam in the similar model of epilepsy. It is suggested that the action of mebicar on the focus of epileptic activity in the cerebral cortex is related to the potentiation of synaptic inhibition of the neurons in the focus of epileptic activity.
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