Abstract
On the 15th day of pregnancy rats were exposed for 2 h to the action of hypoxia equivalent to an altitude of 8000 m, and on the 18th day of pregnancy they were given three injections of [3H]thymidine. A quantitative autoradiographic study was made of the cerebral cortical neurons of the progeny at the age of 30 days. Rats surviving intrauterine hypoxia were shown to have a significantly higher percentage of labeled nerve cells in layers II, III, and V of the sensomotor cortex than in the control. A difference in the intensity of labeling also was found. It is suggested that maternal hypoxia can delay differentiation and maturation of cerebral cortical neurons in the progeny.
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