Abstract
Pregnant rats were kept on a liquid diet containing ethanol (6.8% v/v) from the 13th day of gestation and serum G H levels were determined in the offspring. In neonates exposed to ethanol throughout development, serum growth hormone (GH) secretion was initially increased and then declined to subnormal levels compared to controls. The levels returned to normal after weaning. Withdrawal from ethanol at birth produced similar alterations in serum GH concentrations to those seen in neonatal rats exposed to ethanol continuously. Postnatal exposure to ethanol alone also caused a decrease in GH concentration in rat pups. These data indicate that exposure to ethanol during gestation causes an alteration in the regulation of secretion of GH in the developing pups. A single dose of ethanol given to pups postnatally also caused a marked decline in serum GH levels demonstrating that in the developing pup ethanol can interfere acutely with GH release.
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