Abstract
The present study aims to evaluate the protective role of aqueous extracts of stem and leaves of Tinospora cordifolia (AELTC and AESTC) on the hematologic toxicity effects of ZDV in Rats. A Soxhlet extractor was used to prepare separate aqueous extracts of stem and leaf. Twenty-four albino rats (weighing 200-230 g) were separated into four groups. Group I rats were administered distilled water (negative control). Group II rats were administered 500 mg/kg b.w of ZDV (positive control), Group III rats were administered 500 mg/kg b.w. of AELTC along with ZDV, and Group IV rats were administered 500 mg/kg b.w of AESTC along with ZDV. The hematological parameters of the rats were assayed during the 2nd, 4th, 6th, and 8th weeks of treatment. The animals exposed to Zidovudine showed a significant decrease in Red Blood Cells (RBC), Hemoglobin (Hb), White Blood Count (WBC), and platelet count compared to control (Group I). The results of T. cordifolia leaf and stem administered rats showed a significant elevation in RBC, Hb, WBC, and platelets count. Spleen histology showed immunological and hemorrhagic changes with an accumulation of RBCs and severe depletion of lymphocytes in white pulp were observed in ZDV-treated rats. The intake of AELTC and AESTC showed apparent changes in Spleen tissues. These results suggest that AELTC and AESTC stimulate the hematopoietic system, thereby increasing blood cell levels in ZDV-treated rats.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
