Abstract
Melatonin is effective in treating sleep disturbances, which are closely related to school phobia. However, side effects of melatonin in long-term administration have not been examined fully. In the present study melatonin was administered to 30 patients with school phobia (18 females, 12 males; mean age, 14.8 years) who had no physical, psychiatric, or social problems, but had sleep disturbances. Patients were compared with 27 healthy, age-matched controls. No changes in serum 5-S-cysteinyldopa levels, human skin pigmentation, or the state of puberty were observed in either group. Melatonin appeared to lead to improvements in sleep disturbances.
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