Abstract
Local injection (i.e. injection at the site of tumour inoculation) of strains of C. Parvum which have a significant anti-tumour effect when given systemically (i.e. intravenously or, in the case of subcutaneous tumour transplant, intraperitoneally) strongly inhibits the growth of isogeneic transplants of a fibrosarcoma in intact CBA mice but has little or no effect on subcutaneous transplants of the same tumour in T-cell deprived mice. The anti-tumour effect of local injection of C. parvum, unlike that of systemic injection in this particular tumour system, thus appears to be T-cell dependent.
Highlights
PRELIMINARY observations of our own with a mouse fibrosarcoma, and experiments with other mouse tumours recently reported by Likhite and Halpern (1974) and Scott (1974), have shown that intratumour injection of C. parvum may strongly inhibit tumour growth and under some conditions cause complete regression
We have used as tumour hosts both intact and T-cell deprived mice, because in our own experience (Wooodruff and Dunbar, 1972; Woodruff, Dunbar and Ghaffar, 1973), the anti-tumour effect of systemic injections of active strains of C. parvum in respect of cholanthrene induced sarcomata is maintained in T-cell deficient mice, whereas Scott (1974) has reported that the growth of a mastocytoma, is inhibited by intratumour injection of
All the organisms were injected in the form of a formalin killed suspension by one by comparison with tumour growth in untreated control mice (t 1-91, n 10, P
Summary
Mice.-The recipient mice were either intact adult CBA females (20-22 g) or T-cell deprived CBA females prepared as described previously (Woodruff et al, 1973). All the organisms were injected in the form of a formalin killed suspension by one by comparison with tumour growth in untreated control mice (t 1-91, n 10, P
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