Effect of local administration of tirofiban via arterial catheter on regional blood flow and neurological function in patients with acute ischemic cerebral infarction with thrombolysis time window exceeding

Abstract

Objective To investigate the effects of local administration of tirofiban via arterial catheter on regional blood flow and neurological function in acute ischemic cerebral infarction patients with thrombolysis time window exceeding. Methods A total of 93 patients with acute ischemic cerebral infarction beyond the time window of thrombolytic therapy admitted to Hebi People’s Hospital from October 2016 to April 2018 were selected. All patients were divided into two groups by drawing lots. Forty-six patients in traditional group received routine treatment such as brain cell protection and free radical scavenging, and 47 patients in experimental group were given tirofiban by arterial catheter on the basis of treatment for traditional group. Two weeks after treatment, the neurological function, living ability and cerebral blood flow were compared between the two groups. Results The activities of daily living (ADL) score of experimental group was higher than that of traditional group, and the National Institutes of Health Stroke scale (NIHSS) score was lower than that of traditional group 2 weeks after treatment (P 0.05). Conclusions Local administration of tirofiban via arterial catheter can improve the blood flow of basilar artery and middle cerebral artery in patients with acute ischemic cerebral infarction. It is helpful to improve patients’ living ability and recovery of nervous function, and it is safe and reliable. Key words: Acute ischemic cerebral infarction; Tirofiban; Local administration of transarterial catheter; Nerve function; Brain blood flow