Abstract
The effect of liver extract in pernicious anemia may be analyzed from the point of view of the immediate reaction, as well as of the sustained reaction. The immediate reaction includes among other things 3 distinct morphological features: (1) the normoblastic response, (2) the reticulocyte response, and (3) the liberation of the mature erythrocytes.1 It is a well established fact that the bone marrow in pernicious anemia is hyperplastic and contains large amounts of erythrocytes in various stages of development. In other words, there appears to be a difficulty in the maturation of the erythrocytes necessary for their discharge from the marrow into the circulation. This faulty maturation is in character probably morphological rather than chemical, for the cells in the marrow are completely filled with hemoglobin and products of hemoglobin have been deposited in the various tissues. Thus the hemosiderosis, in the classical interpretation of pernicious anemia looked upon as a proof of the hemolytic character...
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