Abstract
During the 12 months after ligation of the pancreatic ducts in dogs the concentration of endogenous serotonin (5-HT) was studied in the mucous membrane of different parts of the stomach and small intestine, and also in homogenates of pancreatic tissue and in peripheral blood. Considerable and prolonged disturbances of the deposition of endogenous 5-HT were found. The disturbances were characterized by definite patterns for each tissue studied and were connected with changes in the relative constancy of the enteral medium as a result of absence of the pancreatic secretion in the lumen of the alimentary canal.
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