Abstract
In the course of a survey on the physiological role of taurine (2-aminoethanesulfonic acid, C2) and related compounds, we focused attention on the relationships between chemical structures and pharmacological effects. In earlier studies we found that intravenous administration of homotaurine (3-aminopropanesulfonic acid, C3) produced a marked decrease in blood pressure in dogs. Both taurine and N-methyl- or side chain-derivatives of C3 had a weaker effect than C3 (1). These results were much the same as those obtained by Stanton and Woodhouse (2), lino (3), Tsujioka et al. (4) and Takahashi et al. (5) with γ-aminobutyric acid (GABA) derivatives, the carboxylic analogues of C3.
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