Abstract
Previous studies mentioned the beneficial effects of vitamin C on the hemorrhage and wound healing. We evaluated the effects of vitamin C on the hemorrhage, hemoglobin concentration, and wound complications in total abdominal hysterectomy. In this randomized, double-blind, placebo-controlled trial, 80 patients with total abdominal hysterectomy were randomly divided into the study and control groups to receive either intravenous 2g of vitamin C in normal saline or solely normal saline therapy. The first 1-g dose of ascorbic acid was administrated the night before surgery, and the second 1g was administrated during surgery. The mean age of the participants was 37.8±4.8 years with a mean preoperative plasma vitamin C concentration of 5.07±2.1mg/dL, close to the subclinical deficiency. The basal characteristics of both groups were the same. The hemorrhage volume was slightly higher in the control group (345.2±31.8ml vs. 388.1±28.3ml, P<0.001). Intravenous vitamin C administration had a positive effect on reducing hemorrhage during total abdominal hysterectomy. Clinicaltrials.gov.identifier: NCT03965637.
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