Abstract
This study was aimed to evaluate the effects of tramadol hydrochloride on the minimum alveolar concentration of isoflurane (MAC ISO ) in dogs. Six healthy, female German shepherd dogs (aged 1-2 years) were used in this study. Anesthesia was induced by mask induction and maintained with isoflurane in oxygen. Mechanical ventilation maintained the end-tidal CO₂ partial pressure (P ET CO₂) from 35 to 45 mmHg throughout the study. A baseline MAC ISO (MAC ISO B) was determined starting 45 minutes after induction of anesthesia by clamping a pedal digit until gross purposeful movement was detected. After MAC ISO B determination, dogs received a tramadol loading dose of 3 mg/kg followed by a continuous rate infusion (CRI) of 2.6 mg/kg/h. The determination of MAC ISO after administration of tramadol (MAC ISO T) began 20 min after the start of the CRI. Arterial blood pressure and heart rate were recorded continuously and arterial blood samples for blood gas analysis were collected at the end of the equilibration period. Mean ± SD values for the MAC ISO B and MAC ISO T were 1.33 ± 0.04% and 1.23 ± 0.04%, respectively. The MAC ISO B decreased significantly by 7.5 ± 0.2% (P ISO without depression of cardiorespiratory function. Thus, the use of tramadol on inhalation anesthesia with isoflurane in dogs can improve the stability of anesthesia and the quality of recovery.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
