Effect of intermediates of the krebs cycle on blood supply and energy metabolism of the ischemized myocardium

Abstract

The effect of α-ketoglutarate and of sodium succinate on the collateral coronary circulation (CCC) of the ischemic myocardium, the systemic arterial pressure, and the concentrations of lactic and pyruvic acids and glucose in the blood flowing from the zone of ischemia was investigated in acute experiments on dogs. A positive effect of α-ketoglutarate in doses of 6 mg/kg (into the coronary artery) and 60 mg/kg (intravenously) on CCC and on contraction was discovered. Intravenous injection of α-ketoglutarate (12 mg/kg) and succinate (100 mg/kg) considerably reduced the glucose consumption of the ischemized myocardium, which was increased after ligation. Succinate, in all doses, prevented the increase in the lactate concentration in the blood flowing from the zone of ischemia more intensively than α-ketoglutarate. Consequently, α-ketoglutarate and succinate, in certain doses, can be used to correct CCC and the energy provision for the ischemized myocardium.