Abstract
Objective To investigate the effect of insulin resistance on prognosis of chronic heart failure. Methods From January 2011 to December 2014, 62 patients with chronic heart failure were divided into insulin resistance(IR) group (n=33) and non-insulin resistance(N-IR) group (n=29) according to HOMA-IR value and followed up for average 302 days (41-360 d). Cardiac death or readmission were counted as end-point for the purpose of this analysis. Results Ouring the follow up, 45 patients had the cardiac events(27 patients being readmission and 18 patients died of cardiovascular causes). Cox proportional hazard regression model analysis showed that insulin resistance were the major determinants for cardiac event outcomes. Kaplan-Meier analysis showed insulin resistance predicted low survival rate. Conclusions Insulin resistance increases mortality in patients with chronic heart failure. Ameliorating insulin resistance should be an important direction for the treatment of heart failure. Key words: Heart failure; Insulin resistance; Prognosis
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