Abstract
Hexosamine and acid mucopolysaccharide concentrations were measured in the fat-free, dry residue (“stroma”) of epididymal adipose tissue from normal rats and from rats made obese by insulin. The hexosamine concentration was 6.81 ±0.267 (SE) jug/mg stroma over a wide range of body weights in normal rats. Adipose tissue from rats given insulin for from 7 to 28 days contained the same proportion of stroma as that from normal rats, but concentrations of hexosamine and acid mucopolysaccharides within the stroma were greatly reduced. Enzymatic digests of stroma on fractionation yielded evidence of hyaluronic acid, chondroitin sulfate and heparin. Of the 3 fractions, hyaluronic acid was reduced the most by insulin. Serum hexosamine and protein-bound hexose levels were lower, and seromucoid levels were higher, in rats given insulin. It appears, from these and other data cited, that insulin impairs the synthesis of certain structural sugars found in adipose tissue and serum. An increase in the rate of breakdown of...
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