Abstract
The majority of Men C conjugate vaccines given in the UK use CRM 197, a mutant diphtheria toxoid, as their protein carrier. We studied the effects of prior immunisation with Men C–CRM 197 conjugate vaccine on immunity to diphtheria in 193 children before and after a booster dose of Men C at 4 years. Baseline diphtheria antibodies were higher in children given four previous doses of Men C ( P<0.0001) and tended to be higher following boosting in those who had received three or four doses. This enhanced immunity was not associated with increased reactogenicity.
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