Abstract
Results from previous studies suggest that interleukin-1 production is depressed in chronic protein malnutrition. We have investigated the role of arachidonic acid metabolites in the regulation of interleukin-1 production by monocytes of severely protein malnourished rabbis. Indomethacin, a potent inhibitor of prostaglandin synthesis, produced a dose-dependent increase in Staphylococcus epidermidis-induced interleukin-1 production, as measured by a murine thymocyte proliferation assay. Addition of indomethacin alone to thymocyte cultures did not stimulate mitogenesis. These data suggest that arachidonate metabolites, such as the prostaglandins, may be potent down-regulators of interleukin-1 production in protein malnutrition.
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