Abstract
Effect of IL-1 receptor antagonist on the cerebrospinal fluid nitric oxide concentrations during experimental polymicrobial sepsis in rats
Highlights
The project ‘HUPE against sepsis’ seeks to emphasize the importance of early recognition of sepsis, in order to accelerate the implementation of measures associated with decreased mortality for severe sepsis
The study group had greater probability to have a first dose of empirical antibiotic in less than 6 hours compared with the control group (RR 2.48; 95% cardiac index (CI) 1.88 to 3.26)
The aims of this study were to describe a population of cancer patients with severe pneumonia who required ICU admission; identify predictors of hospital mortality; and classify the study population based on ATS CAP/healthcare-associated pneumonia (HCAP) definitions providing a comparison of clinical data, microbiologic variables and outcomes between the two groups
Summary
The project ‘HUPE against sepsis’ seeks to emphasize the importance of early recognition of sepsis, in order to accelerate the implementation of measures associated with decreased mortality for severe sepsis. Materials and methods: To evaluate the reduction in time of antimicrobial adjustment therapy in patients with sepsis comparing a rapid molecular test (SeptiFast®) with conventional blood cultures, a randomized controlled clinical trial was conducted between October 2012 and May 2013 in a cardiology hospital. The aims of this study were to describe a population of cancer patients with severe pneumonia (not acquired in the hospital setting) who required ICU admission; identify predictors of hospital mortality; and classify the study population based on ATS CAP/HCAP definitions providing a comparison of clinical data, microbiologic variables and outcomes between the two groups. Materials and methods: As the diagnostic criteria of the systemic inflammatory response syndrome (SIRS) are very sensitive and very little specific, we selected patients with severe sepsis and septic shock in the first 24 hours of ICU admission, 18 years old or more, with two general and one or more inflammatory criteria of SIRS (ACCP/SCCM/2003).
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