Effect of hyperlipidaemia on oxidative susceptivity of low-density lipoprotein in patients with cerebral infarction

Abstract

Objective To determine the influence of hyperlipidaemia on the oxidative susecptivity of plasma low-density lipoprotein in patients with cerebral infarction.Methods The oxidative susceptivity of plasma low-density lipoprotein were determined in 61 patients with cerebral infarction accompanied by hyperlipidemia in the region of middle cerebral artery,and the size of infarction was resemble.The patients were divided according to the standard of hyperlipidemia below:20 patients were confirmed pertaining to stage Ⅰ(total cholesterol,5.72-6.24 mmol/L;high density lipoprotein,0.78-1.04 mmol/L;low-density lipoprotein 3.64-4.16 mmol/L;triglyeride,3.90-4.42 mmol/L),19 patients were confirmed pertaining to stage Ⅱ(total cholesterol,6.24-6.76 mmol/L;high density lipoprotein,0.52-0.78 mmol/L;low-density lipoprotein,4.16-4.68 mmol/L;triglyeride,4.42-4.94 mmol/L),and 22 patients were confirmed pertaining to stage Ⅲ(total cholesterol,＞6.76;high density lipoprotein,＜0.52 mmoL/L;low-density lipoprotein,＞4.68 mmol/L;triglyeride,＞4.94 mmol/L).Low-density lipoprotein oxidizability was measured by determining the lag time in conjugated diene production at 234 nm by copper-stimulated oxidation.Results The lag time in conjugated diene production in patients with cerebral infarction was negatively correlated with the stage Ⅰ,Ⅱ,Ⅲ of hyperlipidemia in all the subjects(stage Ⅰ,(81.26±7.92)rain;stage Ⅱ,(71.84±9.75)rain;stage Ⅲ,(60.95±9.33)rain.respectively,r=0.751,P＜0.01).Conclusion The oxidative susceptivity of plasma low-density lipoprotein is increased with the increase of hyperlipidemia levels in patients with cerebral infarction. Key words: Hyperlipidaemia; Cerebral infarction; Oxidative low-density lipoprotein