Abstract
Objective To investigate effect of hyperbaric oxygen treatment on infarct size of acute myocardial infarction and on the function of left ventricle in rats. Methods An acute myocardial infarction model was developed by using 50 male SD rats, which were randomly divided into 3 groups: the sham group(12 rats), the acute myocardial infarction group (AMI) (16 rats) and the HBO group(17 rats). Hyperbaric oxygen treatment was applied to the HBO group for a succession of 7 days. Infarct sizes, differences between systolic and diastolic pressures of the three groups and changes in cardiac hemodynamics (± dp/dtmax) were measured 7 days after treatment. Results When compared with that of the AMI group, infarct size and left ventricle function of the HBO group improved significantly (P < 0. 05). Conclusions Early administration of HBO could significantly reduce infarct size and improve left ventricle function of rats with AMI. Key words: Acute myocardial infarction; Hyperbaric oxygen treatment; Left ventricle function; Rat model
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