Abstract
The binding interaction between tRNA and surfactant copper(II) complexes with imidazo(4,5-f)(1, 10) phenanthroline, 6,7,8,9-tetrahydrodipyrido(3,2-a:2 0 ,4 0 -c) phenazine, and benzo(1)dipyrido(3,2-a 0 :2 0 ,3 0 -c)phenazine ligands has been studied using various physicochemical techniques. In the presence of tRNA, UV-Vis spectrum of surfactant complexes showed red shift of the absorption band along with significant hypochromicity indicating intercalation of surfactant complexes with tRNA. Compet- itive binding study with ethidium bromide shows that complexes exhibit the ability to displace the tRNA-bound EB indicating that these complexes bind to tRNA in strong competition with EB for the intercalative binding site. Observed changes in the circular dichroic spectra of tRNA in the presence of surfactant complexes support the strong binding of complexes with tRNA. CV and viscosity results also affirm this mode of binding. The results reveal that the extent of tRNA binding of the benzo(1)dipyrido(3,2-a 0 :2 0 ,3 0 -c) phenazine complex was greater than that of the other com- plexes. Binding to tRNA appears to be mainly intercalative in nature.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
