Abstract
Abstract Introduction: Homocysteine (HCY) is an amino acid that is formed as an intermediate during the metabolism of methionine. The role of hyperhomocysteinemia in the pathogenesis of osteoporosis has been considered
Highlights
Homocysteine (HCY) is an amino acid that is formed as an intermediate during the metabolism of methionine
; the cancellous bone trabeculae were separated by wide bone marrow rich in fat cells associated with a reduction in osteoprotegerin immunoexpression
The aim of the present work is to investigate the structural changes that occur in the bone and epiphyseal plate of femur in young male albino rats after being treated with oral HCY and the possible protective role of folic acid
Summary
Homocysteine (HCY) is an amino acid that is formed as an intermediate during the metabolism of methionine. Osteoporosis is a major health problem that is characterized by low bone mineral density, deterioration of bone microarchitecture and an increased risk of fracture [1]. Osteoporotic fractures are associated with increased level of morbidity and mortality and with substantial economic costs [2,3]. It has been hypothesized that the metabolism of homocysteine is involved in osteoporosis [4]. The presence of homocystinuria is associated with the early onset of generalized osteoporosis [5,6]. The underlying pathophysiological mechanism for the occurrence of early osteoporosis in patients who have homocystinuria is not completely understood [7]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
