Abstract
Male rats were fed for 10 days on a diet containing 333 ppm hexachlorobenzene. Increased microsomal protein levels were noted compared to control rats. On a per g liver basis, the levels of aniline hydroxylase, biphenyl 4-hydroxylase, biphenyl 2-hydroxylase, 4-nitroanisole O-demethylase, esterase, cytochrome P-450 and cytochrome b 5 all increased compared with the control values. On a per mg microsomal protein basis, biphenyl 2-hydroxylase, 4-nitroanisole O-demethylase and cytochrome P-450 levels increased several-fold compared with the control values. It is suggested that, by inducing the 2-hydroxylation reaction, hexachlorobenzene might cause preferential ortho-hydroxylation, as do some carcinogenic polycyclic hydrocarbons, and that in some circumstances this could lead to the formation of carcinogens.
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