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Abstract
Aim: Comparative evaluation of the pH, compressive strength, setting time, and cytotoxicity of mineral trioxide aggregate (MTA) with and without the incorporation of four different accelerators. Methods: 10% CaCl2, 3% Na2SO4, 2% NaCl, and 3% K2SO4 solutions were replaced instead of MTA liquid and mixed with MTA powder (Group B, C, D, and E) and were evaluated for setting time, pH, compressive strength, and cell viability using Gilmore needle, digital pH meter, universal testing machine, and 3-(4,5-dimethylthiazol–2–yl) 2,5-diphenyltetrazolium bromide assay, respectively, and compared with that of MTA (Group A). Results: Group A (control) showed significantly less initial and final setting time. Groups D and E showed a significant decrease in the setting time compared to Groups B and C. Significantly no difference was observed in the pH values, immediately and 3 h after mixing in all groups. The mean compressive strength was greater for Group E followed by the control Groups D, C, and B. About 10% CaCl2 group showed a significant reduction in the compressive strength. Both fresh and set groups showed no significant difference in the cell viability at varying concentrations. Conclusion: Considering its application, as root-end filling and setting time of MTA incorporated with 3% K2SO4 and 2% NaCl have satisfied the requirements as compared to 10% CaCl2 and 3% Na2SO4.
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