Abstract
Blood glucose levels and body weight were assessed to show the biological effects of Trigonella foenum-graecum and Galega officinalis in streptozotocin-induced diabetic rats. Seventy adult female rats were allocated randomly into seven equal independent groups, negative control (n = 10, neither diabetes mellitus (DM) induction nor treatment) and positive control (n = 10, DM induction with streptozotocin (STZ) but no treatment), and the remaining 50 were divided into five equal groups of ten per group, T. foenum-graecum or G. officinalis solutions (1.5 or 3 g/kg) and metformin. Diabetes mellitus was induced by intraperitoneal injection of a single dose of streptozotocin. Blood samples were obtained by tail cut at two time points, 4 days after DM induction and at the end on day 30, and analysed for glucose content, and body weight was recorded on days 0, 4 and 30. Our findings demonstrated that T. foenum-graecum seeds are more potent than G. officinalis leaves with regards to hypoglycaemic properties, but body weight-reducing properties were similar between these two plant species. These results indicated that these two plant species can be used as a herbal treatment for DM and weight gain.
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