Abstract
To investigate the effect of granulocyte colony-stimulating factor (G-CSF) on oral mucositis (OM) and on the healing of traumatic ulcers produced in the tongue of rats undergoing radiotherapy (RT). Twenty-seven Wistar rats were assigned to four groups: (1) RT+ traumatic ulcer+ filgrastim (G-CSF analog; n=7); (2) RT+traumatic ulcer+ saline (n= 7); (3) no RT+ traumatic ulcer+ filgrastim (n= 7); and (4) no RT+ traumatic ulcer (n= 6). The radiation dose was 30 Gy, and medication was filgrastim (10 μg/kg) for 7 days. Clinically, groups differed in the presence (Fisher's exact test: P= .008) and size of traumatic ulcers after irradiation (Kruskal-Wallis test: P= .032) and in the severity of OM (Fisher's exact test: P= .005 between the irradiated groups). Histologically, there was an increased inflammatory response in the nonirradiated groups (Fisher's exact test: P= .001). Filgrastim reduced manifestations and the severity of trauma-induced ulcers and radiation-induced OM. Significant differences were not observed histologically between the study drug and respective control groups.
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