Abstract
Fluoxetine is a prototype of Selective Serotonin Reuptake Inhibitors (SSRIs), with a plasma half-life of 2 days. Fluoxetine is widely and inadvertently used as an antidepressant for various psychiatric illnesses in high doses and for long duration. The aim of present study was to establish the fact that higher doses and long term use of Fluoxetine (SSRI) cause change in the histology of epididymis of albino rats. The present study was carried out on 32 adult male albino rats. Fluoxetine was administered intraperitoneally for 2 weeks, 4 weeks and 12 weeks with mild (10mg/kg/day), moderate (20mg/kg/day) and severe doses (40mg/kg/day). Histological slides were prepared and stained with H and E stain. On examination, Epithelial cell hypertrophy, Intracytoplasmic Vacuolations, intercellular vacuolations, reduced number of spermatozoa, sloughed testicular germ cells and cell debris in the Epididymal lumen were found in treated groups. These changes may cause infertility.
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