Effect of Exercise Rehabilitation Training on Humoral Factors in Patients with Chronic Heart Failure and its Effect Observation

Abstract

Objective:To examine the effects of exercise rehabilitation training on chronic heart failure(CHF)and superoxide dismutase(SOD),homocysteine(Hcy),angiotensinⅡ(AngⅡ),lactic acid(LA)and the effect of brain natriuretic peptide(BNP),providing evidence-based medical evidence for the clinical treatment of CHF.Methods:A total of 76 patients with CHF were divided into control group and combination group,with 38 patients in each group,using the random number table method.The control group received routine drug therapy;the combination group received exercise rehabilitation training in addition of the control group treatment.The effective rate and the changes of various humoral factors were observed before and after treatment.Results:The total effective rate was 89.47%in the combination group while 73.68%in the control group.The total effective rate in the combination group was better than that in the control group(P<0.05).There was no significant difference in the distribution of cardiac function grades between the two groups before treatment(P>0.05).The distribution of cardiac function grades in the combination group was better than that of the control group,and the difference was statistically significant(P<0.05)after treatment.Both groups of patients before treatment the serum Ang-Ⅱ,SOD,Hcy,LA and BNP levels comparison,there were no statistically significant differences(P>0.05);After treatment in patients with serum Ang-Ⅱ,Hcy,LA and BNP levels decreased significantly,the level of SOD increased obviously,the differences were statistically significant(P<0.05).In the combination group after the treatment,the patients serum of Ang-Ⅱ,Hcy,LA and BNP levels decreased,compared with the control group,the differences were statistically significant(P<0.05),the patients level of SOD increased in the combination group,and was better than that of the control group,the difference was statistically significant(P<0.05).Conclusion:Compared with drug therapy alone,combined exercise rehabilitation training on the basis of conventional drug therapy can regulate relevant humoral factors more effectively,affect the vascular endothelial function of CHF patients to a certain extent,reduce the content of LA,enhance cardiac function,with positive curative effect,and it is worthy of clinical application.