Abstract
The functions of many proteins have been directly connected to their conformational changes. The macromolecular crowding environment inside the cell is known to have a significant impact on the equilibria and transition rates between different conformations of the protein. Here we demonstrate the effect of ethanol as crowders on the conformational dynamics of α- synuclein protein, a primary component of the fibrillar neuronal inclusions, and known as Lewy bodies that are diagnostic of Parkinson’s disease. We observed the α-synuclein protein to experience stronger crowding effects with an increase in concentration of ethanol, the crowding agent. The findings that we obtained from this simulation study would serve as valuable guides for expected crowding effects on conformational dynamics of α- synuclein.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
