Abstract
The influence of ethacrynic acid (EA) upon the endolymphatic potential (EP) and the high-energy compounds ATP and P-creatine in the stria vascularis was studied at control conditions and following ischemia. While both EP and high-energy phosphates drop rapidly and at comparable rates due to ischemia and other interferences with energy production (cyanide or dinitrophenol), no major changes in high-energy phosphates occur when EP is severely depressed due to EA intoxication. Moreover, if EA-intoxicated ears are subjected to ischemia the levels of ATP and P-creatine are maintained much longer than in untreated controls, and the decline of EP is much slower with initial rates of change roughly proportional to the preischemic (predamaged) level of EP. These findings, obviously expressions of a reduced metabolic rate, indicate that the early effects of EA upon EP are not caused by an impairment of energy production or by changes in permeability, but rather are due to an interference with energy utilization, most likely by inhibition of the energy consuming processes mediated by the Na+K+-ATPase system.
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