Abstract
Methicillin Resistant Staphylococcuus aureus, (MRSA) is one of the greatly feared strains as it has become resistant to most β- lactam antibiotics due to certain protective enzymes. (1,2) . Alternatively, generation of Reactive Oxygen Species (ROS) creates oxidative stress which can be lethal to such cells. Recently, number of chemicals and dyes found to stimulate the production of ROS in bacterial cells (3,4,9) . Malachite green (MG) is an example of nonflourescent and photosensitizer dye that can be targeted to a particular cellular site and generates singlet oxygen radical i.e., ROS which also helps in the sensitization of antibiotic resistant bacteria. In this study different concentration of Malachite green were used (100-1000 ng/ ml) to find the sensitivity of MRSA. 760 ng/ ml of MG was found to be lethal against MRSA. Keywords: OH radical, Oxidative stress, Malachite green, Methicillin Resistant Staphylococcus aureus, Reactive Oxygen Species.
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