Abstract
Ellagic acid (EA) is a natural dietary polyphenol that has many beneficial properties, including anti-inflammatory, antioxidant, antiviral, antibacterial, and neuroprotective effects. Studies have revealed that EA may modulate seizure activity in chemically induced animal models of seizures. Therefore, the aim of the present study was to investigate the effect of EA on the seizure threshold in two acute seizure tests in male mice, i.e., in the intravenous (i.v.) pentylenetetrazole (PTZ) seizure test and in the maximal electroshock seizure threshold (MEST) test. The obtained results showed that EA (100 mg/kg) significantly elevated the threshold for both the first myoclonic twitch and generalized clonic seizure in the i.v. PTZ seizure test. At the highest dose tested (200 mg/kg), EA increased the threshold for tonic hindlimb extension in the MEST test. EA did not produce any significant changes in motor coordination (assessed in the chimney test) or muscular strength (investigated in the grip-strength test). The plasma and total brain concentration-time profiles of EA after intraperitoneal and oral administration were also determined. Although further studies are necessary to confirm the anticonvulsant activity of EA, our findings suggest that it may modulate seizure susceptibility in animal models.
Highlights
Accepted: 4 August 2021Epilepsy is a chronic neurological disease diagnosed in approximately 65 million people worldwide [1]
Pharmacotherapy is the main form of treatment for epilepsy, but about 30% of epileptic patients remain drug-resistant [2]
We have shown that changes in the serum concentrations of Ellagic acid (EA) (100 mg/kg) following i.p. and p.o. administration follow a similar time-course pattern
Summary
Epilepsy is a chronic neurological disease diagnosed in approximately 65 million people worldwide [1]. The pathomechanism of this disease is still not fully understood. Pharmacotherapy is the main form of treatment for epilepsy, but about 30% of epileptic patients remain drug-resistant [2]. Antiseizure drugs (ASDs) can cause numerous side effects when used alone or in polytherapy. Up to 25% of patients discontinue pharmacotherapy [3]. There is a need to find more effective and safer ASDs, and to explore new therapeutic strategies for epileptic disorders. Plants seem to be a promising source of compounds with anticonvulsant properties
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