Abstract
Eosinophilic granulomatosis with polyangiitis (EGPA) is a vasculitis characterized by multisystemic manifestations, including severe asthma.1 Airflow obstruction and asthma symptoms persist in a high percentage of EGPA patients despite steroid treatment.2 We describe a case of a 36-year-old man previously diagnosed with antineutrophil cytoplasmic antibody (ANCA)-negative EGPA in 2012 based on the presence of marked peripheral blood eosinophilia (2.12 × 109 cells/L; 26%), severe asthma, pulmonary infiltrates at high-resolution chest tomography (HRCT) scan, nasal polyps and peripheral neuropathy, but not heart, gastrointestinal and renal involvement, and absence of direct demonstration of vasculitis.
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