Effect of dobutamine combined with different doses of dopamine on serum levels of inflammatory factors and immune factors in children with severe pneumonia

Abstract

Objective To analyze the effects of different doses of dobutamine and dopamine on serum levels of inflammatory factors and immune factors in children with severe pneumonia. Methods Eighty-two children with severe pneumonia from November 2014 to March 2016 were selected. According to the different doses of dopamine, they were divided into control group (n=41) and study group (n=41). Both groups were treated by regular treatment measures, on this basis, the control group was treated with conventional dose of dopamine and dobutamine, the study group was used dobutamine with small dose of dopamine, both groups were treated for 5 days. We had statistics of clinical efficacy, the incidence of adverse reactions of the two groups, the serum inflammatory factors of interleukin-6 (IL-6), interleukin-8 (IL-8), C-reactive protein (CRP), tumor necrosis factor-α(TNF-α), nuclear factor [TLR2, immune level transcription factor (NF-κB), myeloid differentiation factor 88 (MyD88)] level were compared between the two groups before and after treatment. Results The total effective rate of the study group (95.12%) was higher than that of the control group (85.37%), but the difference was not statistically significant (P>0.05). Before treatment, there was no significant difference in the levels of IL-6, IL-8, CRP, TNF-α, TLR2, NF-κB or MyD88 between the two groups (P>0.05); after treatment, the levels of IL-6, IL-8, CRP, TNF-α, TLR2, NF-κB and MyD88 in study group were better than those in the control group, the differences were statistically significant (P<0.05). The incidence rate of adverse reactions in the study group (4.88%) was significantly lower than that in the control group (21.96%), and the difference was statistically significant (P<0.05). Conclusions The curative effect of dobutamine combined with small dose of dopamine in the treatment of children with severe pneumonia is effective, can effectively improve the level of serum inflammatory factors and immune factors, improve the therapeutic effect, reduce the incidence of adverse reactions, has the value of popularization. Key words: Dobutamine; Dopamine; Severe pneumonia; Inflammatory factors; Immune factors