Abstract
Black foot disease (BFD) is an endemic peripheral vascular disorder confined to a limited area on the Southwest Coast of Taiwan. A preivous study showed that the standardized mortality ratio (SMR) for cancer of the kidney and bladder were significantly greater in BFD-endemic areas. This study was carried out to assess the effect of 36–40 years of water replacement on the occurrence of genitourinary tract (GU) tumours among residents in BFD-endemic areas. This study suggests that replacing artesian well water in BFD hyperendemic areas for 36 to 40 years led to a decreased SMR of GU tumours. This observation supports the previous hypothesis that artesian well water may be an important factor in the development of GU tumours.
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