Abstract
In the present study the influence of designing and development of sustained release (SR) matrix tablets of diclofenac sodium were investigated. The aim was to increase therapeutic efficacy, reduce frequency of administration, and improve patient compliance. Sustained release matrix tablets of diclofenac sodium, were developed by using different drug: gum ratios, using Xanthan gum as matrix former, microcrystalline cellulose as diluent and Polyethylene Glycol (PEG 6000) as release modifier. Formulated tablets were evaluated for friability, hardness, thickness and their relation to the amount of gum: drug ratio and drug release. The drug release was evaluated in different pH, rotation speed and stirrer. All the formulations showed compliance with pharmacopeial standards. Formulation consisting of drug: Gum ratio of 1:0.12 showed sustained release of drug for 12 hours with 89.67% release. The release pattern showed constant kinetics. Thus, (Xanthan Gum) can be used in as effective matrix former.
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