Abstract
ObjectiveThis study investigated the effects of D-ribose and L-cysteine on aluminum-induced testicular damage in male Sprague-Dawley rats.MethodA total number of thirty-five (35) adult male Sprague-Dawley rats were divided into four groups (AD). Group A (comprised five (5) rats) was designated the Control Group that received Physiological Saline; while groups B, C, and D (comprised ten (10) rats) were given 75 mg/kg, 150 mg/kg and 300 mg/kg of body weight of aluminum chloride respectively for 39 days. At day 40, the aluminum-treated groups were subdivided into sub-groups (B1, C1, D1) comprising of five (5) rats each, and 30 mg/kg body weight of Riboceine were administered for twenty (20) days. Groups B, C and D remained on the normal dosage of aluminum chloride for three more weeks (59 days).ResultsAndrological parameters (Sperm count, motility, morphology and testosterone) in the aluminum-treated Groups B and C showed no significant difference in their mean values when compared with their control counterparts, whereas there was a significant reduction in the andrological parameters in Group D rats when compared with the Control animals. Histoarchitecture of the testes "stain with H&E" of Group A, B and C rats appeared normal while Group D rats showed testicular damages with several abnormal seminiferous tubules with incomplete maturation of germinal cell layers and absence of spermatozoa in their lumen; Leydig cells appear hyperplastic. Group B1, C1 and D1 andrological and histological parameters appeared normal.ConclusionRiboceine treatment significantly attenuates aluminum-induced testicular toxicity in male Sprague-Dawley in rats.
Highlights
Mammals’, especially human’s exposure to metals cannot be overlook
Andrological parameters (Sperm count, motility, morphology and testosterone) in the aluminumtreated Groups B and C showed no significant difference in their mean values when compared with their control counterparts, whereas there was a significant reduction in the andrological parameters in Group D rats when compared with the Control animals
Histoarchitecture of the testes “stain with H&E” of Group A, B and C rats appeared normal while Group D rats showed testicular damages with several abnormal seminiferous tubules with incomplete maturation of germinal cell layers and absence of spermatozoa in their lumen; Leydig cells appear hyperplastic
Summary
Metals are ubiquitous and humans can be exposed to it via pollution in the air, water, soil and food, their wide use in industry and long-term persistence in the environment. Aluminum is the most widely distributed trivalent cation, which is usually present in plants, animal tissues and in natural water, in the form of ion. Al occurs naturally in the environment, and it is released due to anthropogenic activities such as mining and industrial uses, in the production of aluminum metal and other forms of Al compounds. A variety of Al compounds are produced and used for different purposes, such as in water treatment, papermaking, fire retardants, fillers, food additives, pharmaceuticals, colors, cosmetics, Aluminum ware and containers
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