Abstract
The principles governing the diurnal rhythm of mitotic activity in tumor cells have not been adequately investigated, and the published findings are conflicting. Some workers found no diurnal changes in the number of mitoses [], 7], but most [4, 6, 9, II] have observed fluctuations in mitotic activity during the 24h period. Differing results have also been obtained regarding the character of the diurnal mitotic rhythm. Nevertheless, quantitative data for the rates of cell multiplication in tumor tissues during the 24-h period are important when assessing the action of mitotic inhibitors. It has recently been shown that the action of compounds and other factors inhibiting cell division in normal [3] and tumor tissues [5, 6, ]0] may vary depending on the phase of the diurnal rhythm of mitosis during which the test procedure was applied.
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