Abstract
The effect of cyclic AMP and some structural analogues on the dark-repair inhibition by caffeine has been studied. Cyclic AMP had no significant effect, contrary to the previous report by Wackeret al. [5], on the dark-repair inhibition by caffeine. Some cyclic AMP derivatives, resistent to hydrolysis by the phosphodiesterase enzyme, were used to investigate the role of phosphodiesterase in dark-repair inhibition by caffeine. These derivatives, when added alone, had no activity on the dark-repair process. Experiments in combination with caffeine showed that these derivatives were unable to reverse the dark-repair inhibition by caffeine. The present data do not support any correlation between the caffeine inhibition of the dark-repair process, and the phosphodiesterase involved in cyclic AMP metabolism.
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