Abstract
Effect of Curcumin on the Plasticity of Inguinal Adipose Tissue in Experimental Model of Hypothyroidism in Rat: Histological Study
Highlights
Obesity and hypothyroidism are two common clinical conditions that have been linked together closely
Curcumin resulted in the appearance of brown like adipocytes in between White Adipose Tissue (WAT) in the inguinal region
Clinical evidence suggested that mild thyroid dysfunction even in the form of subclinical hypothyroidism is linked to significant changes in body weight and represents a risk factor for overweight and obesity [1]
Summary
Obesity and hypothyroidism are two common clinical conditions that have been linked together closely. Clinical evidence suggested that mild thyroid dysfunction even in the form of subclinical hypothyroidism is linked to significant changes in body weight and represents a risk factor for overweight and obesity [1]. Propylthiouracil (PTU) is a thionamide antithyroid drug, which is the mainstay of pharmacologic treatment of Graves’ disease It acts primarily by inhibiting thyroid hormone synthesis through interference with the organic binding of iodide into thyroglobulin, as well as through inhibiting the peripheral conversion of T4 to T3 [2]. The objective of this study was to detect the effect of curcumin on the structure of inguinal adipose tissue of the hypothyroid rat model induced by PTU. This study aimed to explore the effect of curcumin on the structure of inguinal adipose tissue in Propylthiouracil (PTU) induced hypothyroid rat model
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