Abstract
Normal macrophages can be rendered cytotoxic (or “armed”) when incubated with the supernatant of a mixed culture of lymphocytes from a skin allografted mouse and lymphocytes of the skin donor. The Macrophage Arming Factor (MAF) production may occur in vivo during allograft rejection. This chapter discusses the effect of corticosteroid, administered in vivo or added in vitro , on MAF production by sensitized lymphocytes and macrophage arming by MAF. The production of MAF by allografted mice spleen lymphocytes is not altered by the in vivo corticoid administration. The in vitro addition to MLC of corticoid doses—as high as 1 mg M.P. or 10 mg H.H. per ml—do not alter MAF production by sensitized lymphocytes in the presence of donor cells. Treatment of normal macrophage monolayers with corticosteroids modifies their capacity to become cytotoxic when incubated with MAF-rich supernatants. Steroids administered in vivo and in vitro do not inhibit MAF production by sensitized lymphocytes but diminish or abolish the normal macrophage capacity to become armed when treated by MAF. The effect of corticosteroid treatment on graft rejection might be partly due to the loss of sensitivity of the recipient macrophages to arming factors.
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