Effect of Continuous Renal Replacement Therapy on Mortality in the Intensive Care Unit: A Retrospective Analysis

Abstract

Background: In this study, we aimed to retrospectively evaluate the demographic data, clinical diagnoses, laboratory values and scoring systems that may be effective in predicting mortality in patients undergoing continuous renal replacement therapy (CRRT) in our intensive care unit. Materials and Methods: The data of patients who underwent CRRT in our tertiary intensive care unit were retrospectively analyzed. Digital archive data of Intensive Care Units, patients' medical history, laboratory results and nurse observation forms were analyzed. Acute Physiology and Chronic Health Evaluation II (APACHE II), Glasgow Coma score (GCS), Sequential Organ Failure Assessment (SOFA), Crp/Albumin ratio were analyzed at four time points (during ICU admission, before CRRT, after CRRT and discharge) and their effects on mortality were compared. Results: A total of 107 patients were included in our study between 2017 and 2022 and 101 of these cases resulted in mortality. The change in CRP/Albumin values and GCS scores after CRRT compared to before CRRT was not significant (p>0.05), but the decrease in APACHE II (p<0.01) and SOFA (p<0.01) scores were found to be significant in predicting mortality. No significant difference was found in terms of gender and body mass index measurements, use of inotropic agents, length of intensive care unit stay, length of hospital stay and comorbidities (p>0.05). However, age was found to be a risk factor for mortality (p<0.01). Conclusion: Although CRRT is performed in intensive care unit patients for many underlying causes and can improve APACHE II and SOFA scores, no statistically significant relationship was found be-tween CRP/Albumin ratio in predicting the effect of CRRT on mortality