Abstract
Evaluate the effect on sperm parameters of 25 UI of Recombinant FSH daily in men with Oligoasthenoteratozoospermia (OAT) A retrospective, observational study of 180 patients diagnosed with OAT mild to severe at IECH fertility center, from January 2017- January 2021. Volume, sperm count per mL, Percentage of progressive motility and normal morphology and sperm DNA fragmentation were asees prior treatment. Hormonal profile were also evaluated prior treatment. Daily r-FSH 25 UI for 8 weeks was administrated to all the patients. We included 119 sperm samples met inclusion criteria. The average age was 38.32 ± 7.1 years old. Hormonal evaluation showed FSH 6.1±5.4 mUI/mL; LH 4.1±2.5 mUI/mL; Total testosterone 143±220.5 ng/mL; Estradiol 32.3±9.8 pg/mL. Pretreatment semen analysis were: volume 2.5± 1.1 mL, sperm count 6.2±4.3 mill/mL, progressive motility 13.32±9.88%, normal morphology 3.0±4.9, total motile sperm 4.2±4.3. Post-treatment sperm parameter showed volume 2.8±1.9 mL, Sperm count 14.0±20.35%, Progressive motility 23.4±15.8%, normal morphology 1.4±1.3%. Only sperm count and progressive motility showed statistical difference (p=0.05) There is no consensus on the doses and the length of medical and empirical treatment for normogonadotropic men with OAT. Low dose of r-FSH therapy may be beneficial as treatment in idiophatic OAT and aloud longer period of treatment with a moderate investment.
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