Effect of combine therapy of traditional Chinese medicine on the treatment of chronic obstructive pulmonary disease in acute deteriorated stage complicated with respiratory failure

Abstract

Objective To research more effective therapy strategy in chronic obstructive pulmonary disease in acute deteriorated stage complicated with respiratory failure by treatment with traditional Chinese medicine of Qingrehuatan strategy.Method 68 patients of AECOPD complicated with respiratory failure were randomly dirded into two groups.The patients of treatment group were treated with Qingrehuatan Prescriptions combined with routine medicines while the patients of control group were treated with routine medicines only.Blood samples of all patients in two groups were analyzed including blood gas,NF-kb,TNF-α,IL-8 and CRP.Clinical features and life signs were also compared between two groups.Results The data in two groups including NF-κB、TNF-α、IL-8、CRP、blood gas and respiratory function were improved after treatment and the results seemed better in treatment group(P<0.01).The clinical data were improved obviously in 85.3%patients of treatment group while 64.7%patients in control group (P<0.05).Conclusion The strategy of Qingrehuatan can be used effectively in treatment of chronic obstructive pulmonary disease in acute deteriorated stage complieated with respiratory failure.It takes important role not only in infection control and inflammation mediator inhibition but also in relieving systemic inflammation reaction in the patients of AECOPD complicated with respiratory failure. Key words: Pulmonary Disease,Chronic Obstructive; Respiratory insufficiency